Vlog: Glowing flies and CRISPR-Cas9 Illuminate Potential Targets for Cancer Therapy

Fly Eye
The green fluorescent protein signal marks the Cas9 under a fluorescent microscope

By Norman Zielke and Alison Ollikainen

A glowing green light emanates from the end of the corridor. Can you hear that buzzing? A fly-lab set up by Norman Zielke, a researcher in the Taipale lab at the University of Helsinki, is filled wall to wall with tubes containing small fruit flies, and not only that, but when these flies are viewed under a fluorescent microscope, sure enough, as bright as the Northern lights, they glow a beautiful neon green…

…But Why?

In our first vlog from the CoE in Tumor Genetics, Norman explains his work with a gene editing technology called CRISPR-Cas9, his focus on the MYC cancer driver, and the advantages of using fluorescent tags in model organisms in cancer research.

Subtitles available in both Finnish and English from the video settings.